Reduced antioxiadant high-density lipoprotein function in patients with acute coronary syndrome

Abstract Background High-density lipoprotein (HDL) function rather than concentration plays an important role in the pathogenesis of cardiovascular diseases associated with oxidative stress and inflammation such as coronary artery disease (CAD). In last years, has been identified to have a pivotal acute syndrome (ACS). Purpose The aim present study is determine whether reduced antioxidant HDL ACS. Methods 197 patients ACS were prospectively recruited blood samples taken first 48h after enrollment. Patients chronic CCS (n=727) invasively excluded CAD (no CAD, n=498) from another cohort our group served control patients. A validated cell-free biochemical assay was used assessed by increased HDL-lipid peroxide content (HDLox) normalized HDL-C levels mean value pooled serum healthy participants (nHDLox; no units). Results had significantly HDLox compared without (p<0.001, Figure 1A). Prior intake statins did not influenc differences among groups (Figure 1B). regression analysis strong risk factor for presence (odds ratio 4.09 (2.98–5.62), p<0.001, 2). Conclusions peroxidation independent other traditional factors. Funding Acknowledgement Type funding sources: Foundation. Main source(s): BIOX